For AI/ML teams in drug discovery

Great models demand great data

Go from in silico design to physical characterization with Twist.
Get sequence-perfect antibodies, a suite of characterization assays, and AI-ready data in as few as 15 days.

High-fidelity data.
20-day velocity.

Iterate your AI models without bottlenecks with reproducible binding and developability in weeks

130K+Antibodies assayed
>200KProteins exressed
<20 daysTurnaround time
7MData points generated
Trusted by 445+ partners

The challenge

AI is a powerful tool, but it can’t replace the wet lab

AI-based discovery teams often encounter three problems when bridging the gap from code to biology. Only Twist has the specialized capabilities to solve all three:

Power your AI-guided
drug discovery

Twist connects sequence generation to documented,
model-ready data through an integrated suite of products and services.

Step 1: Design

Submit sequences

Input your sequences from your Gen AI platforms to generate DNA or protein production for wet-lab validation.

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Step 2: Build

Submit sequences

With high-quality datasets, researchers can train and refine their AI models. Validate those models with Twist Express Antibodies and high-throughput characterization services to generate data from sequences in as few as 20 days.

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Step 3: Test

Data delivery

Twist enables the validation of your AI outputs for thousands of proteins for binding and developability characteristics. Twist offers custom data delivery formats that are benchmarked against clinical antibody controls to ensure high-quality datasets ready for direct use in your AI and machine learning models.

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Step 4: Build

Submit sequences

With high-quality datasets, researchers can train and refine their AI models. Validate those models with Twist Express Antibodies and high-throughput characterization services to generate data from sequences in as few as 20 days.

Speak to an expert

Have custom or complex project needs?

Whether you’re looking for bespoke data configurations or help with MSA contracts, our team is here to help.

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Why Twist

10+ characterization assays, all in one workflow

Others can only provide binding confirmation. Twist delivers the full developability picture: every data type your AI model needs to train, rank, and advance leads to clinical validation.

Binding assessment assays

Developability assays

Cell-based functional assays


Binding Kinetics: Affinity Ranking (SPR)

Quantitative kinetic profiling across dilution series to confidently rank binders by true affinity (KD).

Binding Kinetics: Affinity Ranking (SPR) - Quantitative kinetic profiling across dilution series to confidently rank binders by true affinity (KD).

On-cell binding confirmation: Flow Cytometry

Validate Your Best Binders on Cells. Get fast, qualitative or quantitative and definitive binding data.

On-cell binding confirmation: Flow Cytometry - Validate Your Best Binders on Cells. Get fast, qualitative or quantitative and definitive binding data.

Biophysical Characterization: Epitope Binning (SPR)

Map competitive binding relationships to identify epitope diversity and guide lead selection.

Biophysical Characterization: Epitope Binning (SPR) - Map competitive binding relationships to identify epitope diversity and guide lead selection.

Developability Suite: Choose from various biophysical assays

Benchmark manufacturing feasibility and sample quality by quantifying production yield, monomeric purity (aSEC), and particle sizing and dispersity indices (DLS) against clinically validated control antibodies and VHHs.

Developability Suite: Choose from various biophysical assays - Benchmark manufacturing feasibility and sample quality by quantifying production yield, monomeric purity (aSEC), and particle sizing and dispersity indices (DLS) against clinically validated control antibodies and VHHs.

Solubility, Aggregation, Stability - DLS/NanoDSF

Rapidly assess developability by quantifying thermal stability (Tm) , onset of aggregation (Tagg), and particle distribution to help rank order leads.

Solubility, Aggregation, Stability - DLS/NanoDSF - Rapidly assess developability by quantifying thermal stability (Tm), onset of aggregation (Tagg), and particle distribution to help rank order leads.

Off-Target Binding – BVP-ELISA & AC-SINS

Detect off-target and polyspecific interactions early to de-risk downstream development.

Off-Target Binding – BVP-ELISA & AC-SINS - Detect off-target and polyspecific interactions early to de-risk downstream development.

High-Throughput Hydrophobicity and Non-Specific Binding

Plate-based screening correlated to gold-standard HIC and CIC to enable high-throughput, decision-ready insights.

High-Throughput Hydrophobicity and Non-Specific Binding - Plate-based screening correlated to gold-standard HIC and CIC to enable high-throughput, decision-ready insights.

Comprehensive Functional Characterization

Customizable assay platforms to evaluate functional potency and mechanism of action across multiple cell types.

Comprehensive Functional Characterization - Customizable assay platforms to evaluate functional potency and mechanism of action across multiple cell types.

Let's talk about your pipeline

Tell us where you are in your AI drug discovery journey. Our scientific team will reach out within one business day to discuss how Twist can accelerate your work.

For Research Use Only.

Not for use in diagnostic procedures.