DNA methylation describes the addition of a methyl group to the DNA molecule, which, in the human genome, most commonly occurs at cytosine nucleotides. These methylated cytosines are often found in concentrated regions known as CpG islands and play a key role in gene expression and function. Whole genome bisulfite sequencing (WGBS) is the gold standard technique for genome-wide CpG analysis; however, it is expensive and provides relatively low depth of coverage. Alternatively, array-based methylation analysis combines sensitivity with lower costs but can only survey a limited number of CpGs (typically up to 850,000), making it unsuitable for biomarker discovery applications. In this webinar, Matteo Tosolini, PhD, will detail how the Twist Human Methylome Panel can overcome these challenges, enabling affordable, sensitive, and high-coverage analysis of over four million CpGs across both DNA strands. *Results from customer experiences are not predictive of results in other cases. Results in other cases may vary.

To deal with rapidly emerging new infectious diseases and mutant strains, we need an expeditious method to identify their pathogens from those of symptoms similar to symptoms of infectious diseases. Twist target enrichment solution with NGS is such a method. Using it in a single experiment, we can specify the infectious disease-causing pathogens out of around 3,000 viruses. Dr. Motooka will discuss how his lab utilizes this method. 新しい感染症、変異株が続々と報告される中、類似する感染症病態の原因を特定するためには網羅的なサーベイが必須となります。次世シークエンスを用いたキャプチャシークエンシングは、3000種を超えるウイルスから包括的で迅速な原因物質の検出を可能にします。本webinarで、大阪大学微生物研究所　元岡先生より広範囲なウイルスからどのように効率的に原因病原体を同定されているかをお話しいただきます。

Rakan Naboulsi | Swedish University of Agricultural Sciences